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Filtered Search Results
Apexbio Technology LLC Eltrombopag 496775-61-2 200mg
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Eltrombopag is a small molecule orally bioavailable non-peptide agonist targeting the thrombopoietin (TPO) receptor also known as c-Mpl receptor Upon activating this receptor pathway eltrombopag promotes intracellular signaling leading to increased proliferation and differentiation of megakaryocyte progenitor cells thereby stimulating platelet production (thrombopoiesis) In biochemical assays eltrombopag shows potent activity exhibiting an IC50 value of approximately 0 69 M As a research tool this compound is utilized widely in studies investigating mechanisms regulating platelet homeostasis thrombocytopenia-related diseases and efforts to elucidate novel therapeutic strategies targeting hematopoietic lineage differentiation
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Apexbio Technology LLC DGAT-1 inhibitor 701232-20-4 200mg
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DGAT-1 inhibitor (CAS 701232-20-4) also known as T863 is an orally active small molecule that selectively inhibits diacylglycerol acyltransferase 1 (DGAT1) DGAT1 is responsible for catalyzing the final step in triglyceride biosynthesis T863 suppresses enzyme activity by specifically binding to the acyl-CoA binding site of DGAT1 exhibiting an IC50 of 15 nM without affecting enzymatic activities of human DGAT2 MGAT2 or MGAT3 This compound serves as a research tool for investigating DGAT1-mediated lipid synthesis and exploring lipid metabolic disorders using cellular and animal models
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AdipoGen Acridine Orange Sol 2 in H2O
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Chemical. CAS 65-61-2. Formula C17H19N3 . HCl. MW 301.81. Acridine Orange hydrochloride salt is a cell-permeable metachromatic fluorescent dye that stains DNA and RNA. It is used as a nucleic acid-selective fluorescent cationic dye useful for cell cycle determination and staining dead cells. Being cell-permeable, it interacts with DNA and RNA by intercalation or electrostatic attractions respectively. When bound to DNA, it is very similar spectrally to fluorescein, with an excitation maximum at 502nm and an emission maximum at 525nm green. When acridine orange associates with RNA, the excitation maximum shifts to 460nm blue, and the emission maximum shifts to 650nm red. Acridine orange will also enter acidic compartments such as lysosomes where it becomes protonated and sequestered. At low pH inside the organelles, it will emit an orange fluorescence peak at 590nm and for optimal endosome visualization a blue light excitation 475nm is used.
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Medchemexpress LLC Nitrendipine | 39562-70-4 | 99.7% | 200 MG
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Nitrendipine (BAY-E-5009) is an orally active dihydropyridine calcium channel blocker, an analog of Nifedipine. It has been shown to induce apoptosis and possess antihypertensive effects. This compound can block alcohol and morphine withdrawal symptoms, reduce right ventricular hypertrophy, and mitigate pulmonary vascular changes induced by intermittent hypoxia. Furthermore, Nitrendipine exhibits anticancer effects on neuroblastoma cells.
- Orally active dihydropyridine calcium channel blocker
- Induces apoptosis
- Provides antihypertensive effects
- Blocks alcohol and morphine withdrawal symptoms
- Reduces right ventricular hypertrophy
- Mitigates pulmonary vascular changes induced by intermittent hypoxia
- Exhibits anticancer effects on neuroblastoma
- Inhibits Cav1.2 current
- Prevents behavioral signs of ethanol withdrawal
- Attenuates lipid peroxidation in the lung
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eMolecules EMOLECULES INC
5000841577 M-PEG12-AMINE 5G
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eMolecules EMOLECULES INC
5000841584 AZIDO-PEG3-AMINE 5G
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Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | 99.90% | 200 MG
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Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, binding to the D2 dopamine receptor with a pKi of 8.05. It is permeable to the blood-brain barrier. This compound also acts as a strong inhibitor of brain nitric oxide synthase (NOS) with an IC50 of 10±2 μM for purified neuronal NOS, and poorly inhibits inducible macrophage NOS (IC50>100 μM). Additionally, it is a potent inhibitor of CYP3A4, with a calculated IC50 value of 1.69 μM.
- Potent dopamine D2/D3 receptor agonist
- Permeable to the blood-brain barrier
- Strong inhibitor of brain nitric oxide synthase (NOS)
- Potent inhibitor of CYP3A4
- Shows anti-immobility action in mice (in FST and TST)
- Potentiates the anti-immobility action of MPE
- Decreases static mechanical allodynia (SMA) score in rats
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Medchemexpress LLC Hydroquinine | 522-66-7 | 99.84% | 326.44 | 5 G
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Hydroquinine | 522-66-7 | 99.84% | 326.44 | 5 G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000772392 2 5 -DIMETHOXY-1 1 100MG
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![Medchemexpress LLC 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[2-(1-azetidinylsulfonyl)phenyl]-7-methyl-2-(3-methyl | 3055550-22-3 | 99.9% | 423.49 g·mol⁻¹ | C20H21N7O2S | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000285839.png-250.jpg)
Medchemexpress LLC 7H-Pyrrolo[2,3-d]pyrimidin-4-amine, N-[2-(1-azetidinylsulfonyl)phenyl]-7-methyl-2-(3-methyl | 3055550-22-3 | 99.9% | 423.49 g·mol⁻¹ | C20H21N7O2S | 10 MG
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EGFR-IN-86 is a small-molecule epidermal growth factor receptor (EGFR) inhibitor reported to have an IC50 of 1.5 nM. It has demonstrated activity in glioblastoma models, inducing apoptosis and causing G2/M cell-cycle arrest in U87 cells. Supplied as a high-purity research compound (99.92%), it is intended for in vitro and preclinical studies. Molecular formula C20H21N7O2S; molecular weight 423.49 g·mol⁻¹.
- Potent EGFR inhibition with a reported IC50 of 1.5 nM.
- Demonstrated activity in glioblastoma models, inducing apoptosis.
- Induces G2/M cell-cycle arrest in U87 cells.
- High purity suitable for research applications.
- Supplied in small research-friendly quantities for laboratory use.
- Molecular formula C20H21N7O2S and molecular weight 423.49 g·mol⁻¹.
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Aobchem AOBCHEM
5000915829 2 5-DIMETHOXY-4- PROPYLTHIO BE
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eMolecules 1056942-37-0 | 1-Bromo-4-chloro-2-(difluoromethoxy)benzene | MFCD14698391 | 250mg
ChemScene | 68-Difluorothiochroman-4-one | 100mg | 569146754 | CS-0131579 | 1097779-72-0 | MFCD11642634 | 200.200 | C9H6F2OS
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Medchemexpress LLC YKL-06-062 | 2172617-16-0 | 99.4% | 50 MG
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YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3, respectively. It increases MITF mRNA expression in a dose-dependent manner (0.0004-16 μM; 3 hours) in human melanocyte cells and UACC62 melanoma cells.
- Second-generation salt-inducible kinase (SIK) inhibitor
- Exhibits IC50 of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3
- Increases MITF mRNA expression in a dose-dependent manner
- Tested in human melanocyte cells and UACC62 melanoma cells
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Ambeed 4 Benzyloxy phenyl boronic ac
(4-(Benzyloxy)phenyl)boronic acid, 146631-00-7, 98%
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Medchemexpress LLC Amikacin (standard) | 37517-28-5 | 99.9% | 200 MG
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Amikacin is a semisynthetic kanamycin analog that is effective against most Gram-negative bacteria, including strains resistant to gentamicin and tobramycin. It exhibits a significant inhibitory effect and can be utilized in bacteriostatic, anti-cancer, and analgesic studies.
- Semisynthetic kanamycin analog
- Effective against most Gram-negative bacteria
- Exhibits significant inhibitory effect
- Can be utilized in bacteriostatic, anti-cancer, and analgesic studies
- Appearance: solid, white to off-white
- Purity: 99.9%
- Molecular weight: 585.60
- Formula: C22H43N5O13
- Recommended storage: 4°C, sealed and dry, away from moisture
- Shipping: room temperature in continental US
- Stable under recommended storage conditions
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